Boldo

Botanical name: Peumus boldus

Parts used and where grown

Boldo is an evergreen shrub or small tree that is native to Chile and is naturalized to the Mediterranean region of Europe. The leaves are used medicinally.¹

Boldo has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings	Health Concerns
	Indigestion and heartburn
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Historical or traditional use (may or may not be supported by scientific studies)

Boldo has a long history of use by the indigenous people of Chile, as a liver tonic and in the treatment of gallstones.

Active constituents

Boldo contains several types of primary constituents, including volatile oils (for example, ascaridole, eucalyptol), flavonoids, and alkaloids. Boldine, which constitutes about one-fourth of the total number of alkaloids present, is the major alkaloid.² Scientists believe that boldine is responsible for the plant’s choloretic (bile stimulating) and diuretic actions.³ In conjunction with other herbs, such as cascara, rhubarb, and gentian, boldo has been reported to improve appetite.⁴ Ascaridole, a compound found in the volatile oil of the plant, has been used as an anti-parasitic agent but is no longer recommended due its to toxic side effects.⁵

How much is usually taken?

Tinctures that are free of ascaridoles are sometimes recommended. People may take 1 ml of tincture three times per day. Volatile oil of boldo is not recommended due to its high ascaridole content.⁶ ⁷ The dried leaf can be used as an infusion at 3 grams per day.

Are there any side effects or interactions?

The German Commission E monograph suggests that only an ascaridole-free preparation should be used internally. Boldo contains terpene-4-ol, an ingredient similar to that found in juniper, and should be avoided by people with kidney disease, as it could cause kidney irritation.⁸ ⁹ In addition, the herb should not be taken during pregnancy or breast-feeding. It should also be avoided by people who have obstruction of the liver bile duct, or severe liver disease.¹⁰ There is one case report of liver damage occurring in a person taking a laxative containing boldo. The herb was suspected, though not proven, to be the cause.¹¹ Excessive use of the herb over long time periods (more than three to four weeks continuously) is not recommended.

At the time of writing, there were no well-known drug interactions with boldo.

References
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1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 95–6.

2. Robbers JE, Tyler VE. Tyler’s Herbs of Choice: The Therapeutic Use of Phytomedicines. New York: Haworth Press, 1999, 74–5.

3. Robbers JE, Tyler VE. Tyler’s Herbs of Choice: The Therapeutic Use of Phytomedicines. New York: Haworth Press, 1999, 74–5.

4. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 46–7.

5. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 46–7.

6. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 46–7.

7. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 93–4.

8. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 93–4.

9. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 46–7.

10. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Publications, 1997, 26.

11. Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236–9.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires March 2007.

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