Aconitum napellus: If a person with restless leg syndrome is very anxious and tends to panic, this remedy may be soothing. Tingling or shooting pains are felt in the legs, and the nervous system is very agitated. The person may be unable to relax and fall asleep — or the sleep is distressing and full of fearful dreams.

Arsenicum album: A person who needs this remedy feels simultaneously restless and exhausted, with feelings of weakness, heaviness, and trembling in the legs. Cramping and burning sensations may also be experienced. Anxiety and a feeling of insecurity may be pronounced. People who need this remedy are often deeply chilly and improved by warmth.

Causticum: This remedy can be helpful if a person has restless legs with sensations of burning and aching, and cramps in the calves and feet. Symptoms are worse in bed at night and often improve with warmth. People needing Causticum often have a tendency toward chronic problems with muscles and tendons, contractures, and muscle weakness. They are often very sensitive to other people’s feelings, and are prone to nervous stress.

Ignatia: This remedy is indicated for sensitive, nervous individuals with a tendency toward twitching and spasms in the muscles. The legs and arms often jerk as the person falls asleep, and sleep may be extremely light. The person may frequently sigh and yawn, or burst into tears or laughter unexpectedly. Problems brought on by grief or emotional stress often respond to this remedy.

Rhus toxicodendron: Overwhelming restlessness that makes a person want to constantly change position, or get up and pace the room at night, suggests a need for this remedy. The person may feel extremely apprehensive when trying to fall asleep and be unable to stay in bed. A tendency toward stiffness and soreness in many joints and muscles—feeling better from both warmth and motion—is a strong indication for Rhus tox.

Sulphur: A person who needs this remedy experiences a drawing feeling in the legs, with burning sensations and restlessness. The legs and feet may heat up during sleep, and the person may throw the covers off, or constantly move the legs to find a cooler spot. Jerking, twitching, and talking during sleep with frequent waking, are other indications for Sulphur.

Zincum metallicum: When restlessness in the legs is distressing and extreme, this remedy may be indicated. The person feels a constant need to move the legs, both at night and in the daytime (although night is usually worse), and the arms may be involved. Sleep is very agitated, with frequent starts and jerking. People who need this remedy are usually excitable and talkative, with active thoughts—although nervous overstimulation and loss of sleep can eventually lead to exhaustion or depression. Alcohol, especially wine, can aggravate the symptoms.