Baclofen

Also indexed as: Apo-Baclofen®, Baclospas®, Balgifen®, Gen-Baclofen®, Lioresal®, Liotec®, Novo-Baclofen®, Nu-Baclo®, PMS-Baclofen®

Baclofen is used to treat muscle spasms associated with multiple sclerosis and spinal cord injury, and it may help with face pain due to trigeminal neuralgia. It is in a class of drugs known as centrally acting skeletal muscle relaxants.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Depletion or interference	None known
Side effect reduction/prevention	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known
Adverse interaction	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Foods and Other Compounds

Food
Baclofen absorption is not affected by food, but the drug should be taken with a meal to minimise stomach upset.¹

Alcohol
Drinking alcohol may enhance the side effects of baclofen, such as drowsiness, dizziness, weakness, and fatigue.² Therefore, people taking baclofen should avoid alcoholic beverages, especially if staying alert is necessary.

References
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1. Peterson GM, McLean S, Millingen KS. Food does not affect the bioavailability of baclofen. Med J Aust 1985;142:689–90.

2. Olin BR, ed. Central Nervous System Drugs, Muscle Relaxants, Centrally Acting. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 1993, 1529–30.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires March 2007.

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Interactions with Foods and Other Compounds