Loop Diuretics

Also indexed as: Apo-Furosemide®, Betinex®, Bumetanide, Bumex®, Burinex®, Demadex®, Dryptal®, Edecrin®, Ethacrynic Acid, Froop®, Frusol®, Furosemide, Lasix®, Rusyde®, Sodium Edecrin®, Torem®, Torsemide

Loop diuretics constitute a family of drugs that remove water from the body. They are referred to as potassium-depleting, as they cause the body to lose potassium as well as water. Potassium-depleting diuretics also cause the body to lose magnesium. Loop diuretics are more potent than thiazide diuretics. They are used to lower blood pressure in people with hypertension and to reduce the amount of work the heart has to do, allowing it to pump better in people with congestive heart failure. Loop diuretics are also used to reduce water accumulation caused by other diseases.

The information in this article pertains to loop diuretics in general. The interactions reported here may not apply to all the Also Indexed As terms. Talk to your doctor or chemist if you are taking any of these drugs.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.	Folic acid* Magnesium Potassium Vitamin B1
Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.	Alder Buckthorn* Buchu Buckthorn* Cleavers Dandelion Digitalis Gravel root Horsetail Juniper Liquorice Uva ursi
Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.	Sodium
Side effect reduction/prevention	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Dietary Supplements

Folic acid
One study showed that people taking diuretics for more than six months had dramatically lower blood levels of folic acid and higher levels of homocysteine compared with individuals not taking diuretics.¹ Homocysteine, a toxic amino acid by-product, has been associated with atherosclerosis. Until further information is available, people taking diuretics for longer than six months should probably supplement with folic acid.

Magnesium and Potassium
Potassium-depleting diuretics, including loop diuretics, cause the body to lose potassium. Loop diuretics may also cause cellular magnesium depletion,² although this deficiency may not be reflected by a low blood level of magnesium.³ Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including loop diuretics, should supplement both potassium and magnesium.⁴

People taking loop diuretics should be monitored by their doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.⁵ Fruit is high in potassium, and increasing fruit intake is another way of supplementing potassium. Magnesium supplementation is typically 300–400 mg per day.

Vitamin B1
People with congestive heart failure (CHF) treated with the loop diuretic furosemide may be at risk for vitamin B1 deficiency due to: 1) the disease, 2) treatment with furosemide, and/or 3) inadequate dietary vitamin B1 intake.⁶ In a study of people with CHF, long-term furosemide therapy was associated with clinically significant vitamin B1 deficiency due to urinary losses.⁷ This furosemide-induced vitamin B1 deficiency may worsen heart function in patients with CHF and may be prevented or corrected with vitamin B1 supplementation.⁸

Sodium
Diuretics, including loop diuretics, cause increased loss of sodium in the urine. By removing sodium from the body, diuretics also cause water to leave the body. This reduction of body water is the purpose of taking diuretics. Therefore, there is usually no reason to replace lost sodium, although strict limitation of salt intake in combination with the actions of diuretics can sometimes cause excessive sodium depletion. On the other hand, people who restrict sodium intake and in the process reduce blood pressure may need to have their dose of diuretics lowered.

Interactions with Herbs

Herbs that have a diuretic effect should be avoided when taking diuretic medications, as they may enhance the effect of these drugs and lead to possible cardiovascular side effects. These herbs include dandelion, uva ursi, juniper, buchu, cleavers, horsetail, and gravel root.⁹

Alder Buckthorn, Buckthorn(Rhamnus catartica, Rhamnus frangula, Frangula alnus)
Use buckthorn or alder buckthorn for more than ten days consecutively may cause a loss of electrolytes (especially the mineral potassium). Medications that also cause potassium loss, such as some diuretics, should be used with caution when taking buckthorn or alder buckthorn.¹⁰

Digitalis (Digitalis purpurea)
Digitalis refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin. Loop diuretics can increase the risk of digitalis-induced heart disturbances.¹¹ Loop diuretics and digitalis-containing products should only be used under the direct supervision of a doctor trained in their use.

Liquorice (Glycyrrhiza glabra)
Liquorice may enhance the side effects of potassium-depleting diuretics, including loop diuretics.¹² Loop diuretics and liquorice should be used together only under careful medical supervision. Deglycyrrhizinated liquorice (DGL) may be used safely with all diuretics.

Interactions with Foods and Other Compounds

Food
Furosemide (Lasix®) is most effective taken on an empty stomach, one hour before eating.¹³ However, furosemide may be taken with food to prevent gastrointestinal (GI) upset.¹⁴ Torsemide (Demadex®) may be taken with or without food.¹⁵

References
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1. Morrow LE, Grimsley EW. Long-term diuretic therapy in hypertensive patients: effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations. South Med J 1999;92:866–70.

2. Martin B, Milligan K. Diuretic-associated hypomagnesiumia in the elderly. Arch Intern Med 1987;147:1768–71.

3. Kroenke K, Wood DR, Hanley JF. The value of serum magnesium determination in hypertensive patients receiving diuretics. Arch Intern Med 1987;147:1553–6.

4. Whang R, Whang DD, Ryan MP. Refractory potassium repletion—a consequence of magnesium deficiency. Arch Intern Med 1992;152:40–5.

5. Wahr JA, Parks R, Boisvert D, et al. Preoperative serum potassium levels and perioperative outcomes in cardiac surgery patients. JAMA 1999;281:2203–10.

6. Brady JA, Rock CL, Horneffer MR. Thiamin status, diuretic medications, and the management of congestive heart failure. J Am Dietet Assoc 1995;95:541–4.

7. Seligman H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: A pilot study. Am J Med 1991;91:151–5.

8. Shimon I, Almog S, Vered Z, et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med 1995;98:485–90.

9. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Institute, 1997, 102–3.

10. European Scientific Cooperative on Phytotherapy (ESCOP). Frangulae cortex, frangula bark. Monographs on the Medicinal Uses of Plant Drugs. Exeter, UK: University of Exeter, Centre for Complementary Health Studies, 1997.

11. Threlkeld DS, ed. Diuretics and Cardiovasculars, Thiazides and Related Diuretics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons Drug Information, Apr 1993, 135a–7c.

12. Shintani S, Murase H, Tsukagoshi H, Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of two cases and review of the literature. Eur Neurol 1992;32:44–51.

13. Threlkeld DS, ed. Diuretics and Cardiovasculars, Loop Diuretics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1994, 137d–8.

14. Threlkeld DS, ed. Diuretics and Cardiovasculars, Loop Diuretics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1994, 137d–8.

15. Threlkeld DS, ed. Diuretics and Cardiovasculars, Loop Diuretics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr 1994, 137d–8.

Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires March 2007.

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Interactions with Dietary Supplements

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Interactions with Foods and Other Compounds