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Pentoxifylline

Also indexed as: Albert Pentoxifylline®, Apo-Pentoxifylline®, Nu-Pentoxifylline-SR®, Oxpentifylline, Pentoxil®, Trental®

Illustration

Pentoxifylline decreases blood thickness and improves red blood cell flexibility. Pentoxifylline is used to improve symptoms of intermittent claudication and in the treatment of other circulatory disorders.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Beneficial May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better.

Vitamin E

Depletion or interference

None known

Side effect reduction/prevention

None known

Reduced drug absorption/bioavailability

None known

Adverse interaction

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

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Interactions with Dietary Supplements

Vitamin E
The combination of vitamin E and pentoxifylline has been used successfully to reduce damage to normal tissues caused by radiation therapy.1

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Interactions with Foods and Other Compounds

Food
Pentoxifylline should be taken with meals.2

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References
(To view, roll mouse over heading; to hide, click on heading)

1. Delanian S, Balla-Mekias S, Lefaix JL. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol 1999;17:3283–90.

2. Threlkeld DS, ed. Blood Modifiers, Hemorheologic Agent, Pentoxifylline. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997, 89f–9g.

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