Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin (vitamin B1). Benfotiamine is fat-soluble, more bioavailable, and physiologically active than thiamine.* Benfotiamine helps maintain healthy cells in the presence of blood glucose, supports against oxidative stress, and supports healthy aging.
Doctor's Best Benfotiamine + Alpha-Lipoic Acid helps maintain healthy cells in the presence of blood glucose and provides support against oxidative stress and supports healthy aging
Benfotiamine helps protect oxidative stress induced by advanced glycation end-products
Alpha-Lipoic Acid supports the body's defense against free radicals and recycles antioxidant nutrients such as Vitamin C and Vitamin E
Alpha-lipoic acid is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Because it is soluble in both water and fat, alpha-lipoic acid is sometimes referred to as the "universal antioxidant"
Benfotiamine raises the blood level of thiamin pyrophosphate, the biologically active coenzyme of thiamin, and stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Benfotiamine was shown to cause, on average, a 5-fold greater increase in blood thiamine levels than thiamin mononitrate, with a concomitant greater thiamine concentration in red blood cells. Benfotiamine readily passes through intestinal cells and is converted into thiamin. Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling and concentration in liver cells. Aging is associated with oxidative stress in the brain. The brain's high rate of metabolism and its long-lived neurons make it particularly vulnerable to oxidative stress. Since alpha-lipoic acid interrupts cellular oxidative processes in both its oxidized and reduced forms, it plays a modulatory role in the brain and nervous system.
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