Doctor's Best Flavonoid Complex with Sytrinol(R) helps maintain normal cholesterol levels in healthy individuals.* Flavonoid Complex with Sytrinol(R) is a patented formula that combines citrus flavonoids with palm-sourced tocotrienols to promote potent antioxidant effects. Polymethoxylated flavones are the predominant flavonoids found in Sytrinol, the two most prevalent being tangeretin and nobiletin.
Research into the way polymethoxylated flavones modulate the production of lipids has revealed potential mechanisms of action. An in vitro experiment showed that tangeretin could modulate the production of triglycerides on an enzymatic level. Triglycerides are an important component of the body's lipid profile, and play a role in human health. Microsomal triglyceride transfer protein and diacylglycerol acyltransferase are two components of triglyceride synthesis and transport within the cells. Tangeretin displayed inhibitory effects on microsomal triglyceride transfer protein and suppressed the activity of diacylglycerol acyltransferase, thereby influencing triglyceride metabolism. A subsequent in vitro study looked at the effects of nobiletin, the second major polymethoxylated flavones present in Flavonoid Complex with Sytrinol. The results showed nobiletin to possess important free radical scavenging effects in the bloodstream.