Life Extension Optimised Folate L-Methylfolate

Size / Quantity 1000mcg, 100 Vegetarian Tablets

  • Our Price: £12.62
  • RRP: £15.60
  • You Save: £2.98 (19%)

Folate helps maintain homocysteine levels within the normal range, which promotes cardiovascular health. And it also supports neurotransmitter synthesis — which in turn helps maintain cognitive abilities. However, not everyone has sufficient activity of the enzyme required to convert folate to its biologically active form, 5-methyltetrahydrofolate, or 5-MTHF. That's why each vegetarian tablet of Optimized Folate provides 1,000 mcg of the bioactive 5-MTHF form of folate which is up to 7 times more bioavailable than ordinary folic acid.

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  • Supports cardiovascular health
  • Supports neurotransmitter synthesis and critical enzyme reactions
  • Maintains healthy homocysteine levels
Optimal levels of folate are necessary for healthy cell division and protein synthesis and are especially important for the maintenance of a healthy GI tract. The systemic need for folate increases in certain states in which increased cell multiplication is needed.

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).

Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active.

People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.
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Keep all supplements out of sight and reach of young children. Do not exceed the stated recommended intake. Content on this site is not intended to substitute advice given by a medical practitioner, pharmacist, or other licensed health-care professional. Contact your health-care provider immediately if you suspect that you have a medical condition. These products are not intended to be used to diagnose, treat, cure, or prevent any disease or health condition. Food supplements must not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Adverse reactions to supplements are rare, but if you experience an adverse reaction stop taking the product and contact your practitioner. Sometimes a supplement will suit one person but not another.

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